Article
The targeted disruption of the MYPT1 gene results in embryonic lethality.
Transgenic research - 1 Jun 2005
Okamoto Ryuji, Ito Masaaki, Suzuki Noboru, Kongo Mariko, Moriki Nobuyuki, Saito Hiromitsu, Tsumura Hideki, Imanaka-Yoshida Kyoko, Kimura Kazushi, Mizoguchi Akira, Hartshorne David J, Nakano Takeshi
Abstract excerpt
Myosin phosphatase (MP) is a major phosphatase responsible for the dephosphorylation of the regulatory light chain of myosin II. MYPT1, a target subunit of smooth and nonmuscle MP, is responsible for activation and regulation of MP. To identity the physiological roles of MP, we have generated MYPT1-deficient mice by gene targeting. The heterozygous mice showed no changes in expression levels of MYPT1 and no...
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