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Article

TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin.

PloS one - 1 Jan 2012

Kathrani Aarti, Holder Angela, Catchpole Brian, Alvarez Lorena, Simpson Kenneth, Werling Dirk, Allenspach Karin

Abstract excerpt

Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease. We recently demonstrated a significant association between three non-synonymous SNPs in the canine TLR5 gene and IBD in German shepherd dogs (GSDs). However, so far, no direct link between these SNPs and a disturbance in TLR5 function was shown. In the present...

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Identifiers

PMID: 22279566
DOI: 10.1371/journal.pone.0030117
PMCID: PMC3261174

Genes

TLR5
CXCL8
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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