Article
The impact of brain-derived neurotrophic factor Val66Met polymorphism on cognition and functional brain networks in patients with intractable partial epilepsy.
CNS neuroscience & therapeutics - 1 Feb 2019
Sidhu Meneka K, Thompson Pamela J, Wandschneider Britta, Foulkes Alexandra, de Tisi Jane, Stretton Jason, Perona Marina, Thom Maria, Bonelli Silvia B, Burdett Jane, Williams Elaine, Duncan John S, Matarin Mar
Abstract excerpt
INTRODUCTION: Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls...
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