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Article

Allele-specific replication associated with aneuploidy in blood cells of patients with hematologic malignancies.

Cancer genetics and cytogenetics - 1 Dec 2002

Korenstein-Ilan Avital, Amiel Aliza, Lalezari Shadan, Lishner Michael, Avivi Lydia

Abstract excerpt

We hypothesize that coordination between the two DNA parental sets in somatic cells is essential for the stability of the diploid genome, and that its disruption is associated with the many alterations observed in the various cancerous phenotypes. As coordination between two allelic counterparts is well exemplified by synchrony in replication timing, we examined, in blood cells of patients suffering from various...

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PMID: 12550768
DOI: 10.1016/s0165-4608(02)00610-6

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