Article
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.
PLoS genetics - 1 Apr 2013
Abreu Carla Manuela, Kumar Ramesh, Hamilton Danielle, Dawdy Andrew William, Creavin Kevin, Eivers Sarah, Finn Karen, Balsbaugh Jeremy Lynn, O'Connor Rosemary, Kiely Patrick A, Shabanowitz Jeffrey, Hunt Donald F, Grenon Muriel, Lowndes Noel Francis
Abstract excerpt
The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. Here we show that cell cycle phosphorylation of the prototypical DDR mediator Saccharomyces cerevisiae Rad9 depends on cyclin-dependent kinase (CDK) complexes. We find that a specific G2/M form of Cdc28 can phosphorylate in vitro the N-terminal...
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