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Article

A domain of Rad9 specifically required for activation of Chk1 in budding yeast.

Journal of cell science - 1 Feb 2004

Blankley Richard T, Lydall David

Abstract excerpt

The Rad9 protein is a key adaptor protein in Saccharomyces cerevisiae DNA damage checkpoint pathways. Its adaptor function is to link the activity of the Mec1 kinase to the activation of two parallel signalling pathways dependent on the Rad53 and Chk1 kinases. The mechanisms by which Rad9 interacts with, and activates, Rad53 are well understood. However, little was known about how Rad9 facilitates the activation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14709724
DOI: 10.1242/jcs.00907

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A domain of Rad9 specifically required for activation of Chk1 in budding yeast.PMID 14709724Read ↗

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.Semantic proximity Read ↗

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.Semantic proximity Read ↗

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint.Semantic proximity Read ↗

A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.Semantic proximity Read ↗

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.Semantic proximity Read ↗

Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism.Semantic proximity Read ↗

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.Semantic proximity Read ↗

Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicasesSemantic proximity Read ↗

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationSemantic proximity Read ↗

Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteinsSemantic proximity Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Semantic proximity Read ↗

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