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Article

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.

Genes & development - 15 May 2004

Furuya Kanji, Poitelea Marius, Guo Liandi, Caspari Thomas, Carr Antony M

Abstract excerpt

To gain insight into the function and organization of proteins assembled on the DNA in response to genotoxic insult we investigated the phosphorylation of the Schizosaccharomyces pombe PCNA-like checkpoint protein Rad9. C-terminal T412/S423 phosphorylation of Rad9 by Rad3(ATR) occurs in S phase without replication stress. Rad3(ATR) and Tel1(ATM) phosphorylate these same residues, plus additional ones, in response...

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Source

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Identifiers

PMID: 15155581
DOI: 10.1101/gad.291104
PMCID: PMC415640

Genes

ATR
TOPBP1
ATM
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.PMID 15155581Read ↗

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.Semantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.Semantic proximity Read ↗

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.Semantic proximity Read ↗

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.Semantic proximity Read ↗

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Semantic proximity Read ↗

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.Semantic proximity Read ↗

Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress.Semantic proximity Read ↗

Critical Function of γH2A in S-Phase.Semantic proximity Read ↗

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage.Semantic proximity Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

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