Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.

Cell cycle (Georgetown, Tex.) - 15 Oct 2012

Wang Guoliang, Tong Xiangyan, Weng Stephanie, Zhou Huilin

Abstract excerpt

The DNA damage checkpoint controls cell cycle arrest in response to DNA damage, and activation of this checkpoint is in turn cell cycle-regulated. Rad9, the ortholog of mammalian 53BP1, is essential for this checkpoint response and is phosphorylated by the cyclin-dependent kinase (CDK) in the yeast Saccharomyces cerevisiae. Previous studies suggested that the CDK consensus sites of Rad9 are important for its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cell Cycle Proteins
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to Gene Expression Regulation, Fungal

Share to Phosphorylation

Share to Saccharomyces cerevisiae Proteins

Share to Schizosaccharomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 23070520
DOI: 10.4161/cc.21987
PMCID: PMC3495822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation.PMID 23070520Read ↗

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.Semantic proximity Read ↗

A domain of Rad9 specifically required for activation of Chk1 in budding yeast.Semantic proximity Read ↗

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.Semantic proximity Read ↗

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.Semantic proximity Read ↗

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.Semantic proximity Read ↗

Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism.Semantic proximity Read ↗

A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.Semantic proximity Read ↗

Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint.Semantic proximity Read ↗

Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.