Article
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
NMR in biomedicine - 1 Oct 2013
Choi Changho, Ganji Sandeep, Hulsey Keith, Madan Akshay, Kovacs Zoltan, Dimitrov Ivan, Zhang Song, Pichumani Kumar, Mendelsohn Dianne, Mickey Bruce, Malloy Craig, Bachoo Robert, Deberardinis Ralph, Maher Elizabeth
Abstract excerpt
2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The (1) H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed...
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