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Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B0 -shim array coils at 3 T.

NMR in biomedicine - 1 Jan 2022

Strasser Bernhard, Arango Nicolas S, Stockmann Jason P, Gagoski Borjan, Thapa Bijaya, Li Xianqi, Bogner Wolfgang, Moser Philipp, Small Julia, Cahill Daniel P, Batchelor Tracy T, Dietrich Jorg, van der Kouwe Andre, White Jacob, Adalsteinsson Elfar, Andronesi Ovidiu C

Abstract excerpt

MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B0 spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that...

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PMID: 34609036
DOI: 10.1002/nbm.4621
PMCID: PMC8717863

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