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Article

MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T.

Journal of magnetic resonance imaging : JMRI - 1 Oct 2016

Bisdas Sotirios, Chadzynski Grzegorz L, Braun Christian, Schittenhelm Jens, Skardelly Marco, Hagberg Gisela E, Ethofer Thomas, Pohmann Rolf, Shajan G, Engelmann Jörn, Tabatabai Ghazaleh, Ziemann Ulf, Ernemann Ulrike, Scheffler Klaus

Abstract excerpt

PURPOSE: To examine in vivo metabolic alterations in the isocitrate dehydrogenase (IDH) mutated gliomas using magnetic resonance spectroscopy (MRS) at magnetic field 9.4T. MATERIALS AND METHODS: Spectra were acquired with a 9.4T whole-body scanner with the use of a custom-built head coil (16 channel transmit and 31 channel receive). A modified stimulated echo acquisition mode (STEAM) sequence was used for...

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PMID: 26970248
DOI: 10.1002/jmri.25221

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