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A comparison of 2‐hydroxyglutarate detection at 3 and 7 T with long‐TE semi‐LASER

5 Jan 2018

Abstract excerpt

Abnormally high levels of the 'oncometabolite' 2-hydroxyglutarate (2-HG) occur in many grade II and III gliomas, and correlate with mutations in the genes of isocitrate dehydrogenase (IDH) isoforms. In vivo measurement of 2-HG in patients, using magnetic resonance spectroscopy (MRS), has largely been carried out at 3 T, yet signal overlap continues to pose a challenge for 2-HG detection. To combat this, several...

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PMID: 29315915
DOI: 10.1002/nbm.3886

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