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Article

A novel human Smad4 mutation is involved in papillary thyroid carcinoma progression.

Endocrine-related cancer - 1 Feb 2012

D'Inzeo Sonia, Nicolussi Arianna, Donini Caterina Francesca, Zani Massimo, Mancini Patrizia, Nardi Francesco, Coppa Anna

Abstract excerpt

Smad proteins are the key effectors of the transforming growth factor β (TGFβ) signaling pathway in mammalian cells. Smad4 plays an important role in human physiology, and its mutations were found with high frequency in wide range of human cancer. In this study, we have functionally characterized Smad4 C324Y mutation, isolated from a nodal metastasis of papillary thyroid carcinoma. We demonstrated that the stable...

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Source

Identifiers

PMID: 22109972
DOI: 10.1530/ERC-11-0233

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