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Article

SMAD4 gene promoter mutations in patients with thyroid tumors.

Experimental and molecular pathology - 1 Aug 2015

Nikolic Aleksandra, Ristanovic Momcilo, Zivaljevic Vladan, Rankov Aleksandra Divac, Radojkovic Dragica, Paunovic Ivan

Abstract excerpt

As a key component of the transforming growth factor beta (TGFB) pathway, which regulates the expression of thyroid-specific genes, tumor suppressor SMAD4 is crucial for thyroid development and function. Aberrant expression of SMAD4 in thyroid tumor tissue was reported and mutations affecting the coding region have been detected, but a potential role of mutations in SMAD4 gene regulatory regions remains...

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Share to Gene Expression Regulation, Neoplastic
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Promoter Regions, Genetic

Share to Smad4 Protein

Share to Thyroid Gland

Share to Thyroid Neoplasms

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Source

Identifiers

PMID: 26079547
DOI: 10.1016/j.yexmp.2015.06.005

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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