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Article

Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.

Biochemistry - 4 Dec 2007

Prokova Vassiliki, Mavridou Sofia, Papakosta Paraskevi, Petratos Kyriacos, Kardassis Dimitris

Abstract excerpt

Smad proteins are the key effectors of the transforming growth factor beta (TGFbeta) signaling pathway in mammalian cells. The importance of Smads for human physiology is documented by the identification and characterization of mutations that are frequently found in cancer patients. In the present study we have functionally characterized such a tumorigenic mutation in Smad4 (E330A) and shown that this mutant as...

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PMID: 17994767
DOI: 10.1021/bi701540u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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