Article
Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.
American journal of physiology. Cell physiology - 1 Oct 2003
Roelen Bernard A J, Cohen Ori S, Raychowdhury Malay K, Chadee Deborah N, Zhang Ying, Kyriakis John M, Alessandrini Alessandro A, Lin Herbert Y
Abstract excerpt
Smad4, the common Smad, is central for transforming growth factor (TGF)-beta superfamily ligand signaling. Smad4 has been shown to be constitutively phosphorylated (Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin C-H, Miyazono K, and ten Dijke P. EMBO J 16: 5353-5362, 1997), but the site(s) of phosphorylation, the kinase(s) that performs this phosphorylation, and...
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