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Article

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.

Molecular and cellular endocrinology - 24 Sept 2009

Guigon Celine J, Cheng Sheue-yann

Abstract excerpt

The thyroid hormone receptors (TRs) are transcription factors that mediate the pleiotropic activities of the thyroid hormone, T3. Four T3-binding isoforms, TRalpha1, TRbeta1, TRbeta2, and TRbeta3, are encoded by two genes, THRA and THRB. Mutations and altered expression of TRs have been reported in human cancers. A targeted germ-line mutation of the Thrbeta gene in the mouse leads to spontaneous development of...

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Source

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Identifiers

PMID: 19549593
DOI: 10.1016/j.mce.2009.01.007
PMCID: PMC2744088

Genes

THRA
THRB

Provenance

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