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Article

Acceleration of BRAFV600E-induced thyroid carcinogenesis by TGFβ signal deficiency in mice.

Endocrine - 1 Sept 2020

Shimamura Mika, Kurashige Tomomi, Kuatov Rassul, Nakashima Masahiro, Nagayama Yuji

Abstract excerpt

PURPOSE: Transforming growth factor-β (TGFβ) has pleiotropic actions, including both anti- and pro-tumorigenic abilities. We have previously shown no tumor development in the thyroid-specific TGFβ receptor type II knockout (Tgfβr2 KO) mice, indicating the insufficiency of defective TGFβ signal itself for thyroid cancer initiation. In the current study, we evaluated whether defective TGFβ signal accelerates...

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Source

Identifiers

PMID: 32281047
DOI: 10.1007/s12020-020-02298-1

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TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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