Article
Definition of smad3 phosphorylation events that affect malignant and metastatic behaviors in breast cancer cells.
Cancer research - 1 Nov 2014
Bae Eunjin, Sato Misako, Kim Ran-Ju, Kwak Mi-Kyung, Naka Kazuhito, Gim Jungsoo, Kadota Mitsutaka, Tang Binwu, Flanders Kathleen C, Kim Tae-Aug, Leem Sun-Hee, Park Taesung, Liu Fang, Wakefield Lalage M, Kim Seong-Jin, Ooshima Akira
Abstract excerpt
Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 linker region becoming highly phosphorylated. Here, we report, for the first time, that mutation...
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