Article
Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer.
European journal of human genetics : EJHG - 1 Jan 2014
Larson Nicholas B, Jenkins Gregory D, Larson Melissa C, Vierkant Robert A, Sellers Thomas A, Phelan Catherine M, Schildkraut Joellen M, Sutphen Rebecca, Pharoah Paul P D, Gayther Simon A, Wentzensen Nicolas, Goode Ellen L, Fridley Brooke L
Abstract excerpt
Although single-locus approaches have been widely applied to identify disease-associated single-nucleotide polymorphisms (SNPs), complex diseases are thought to be the product of multiple interactions between loci. This has led to the recent development of statistical methods for detecting statistical interactions between two loci. Canonical correlation analysis (CCA) has previously been proposed to detect...
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