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Article

Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.

Human genetics - 1 May 2014

Xiao Feifei, Ma Jianzhong, Cai Guoshuai, Fang Shenying, Lee Jeffrey E, Wei Qingyi, Amos Christopher I

Abstract excerpt

Epistasis, or gene-gene interaction, results from joint effects of genes on a trait; thus, the same alleles of one gene may display different genetic effects in different genetic backgrounds. In this study, we generalized the coding technique of a natural and orthogonal interaction (NOIA) model for association studies along with gene-gene interactions for dichotomous traits and human complex diseases. The NOIA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24241239
DOI: 10.1007/s00439-013-1392-2
PMCID: PMC4423532

Genes

HERC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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