Article
BayesKAT: bayesian optimal kernel-based test for genetic association studies reveals joint genetic effects in complex diseases.
Briefings in bioinformatics - 27 Mar 2024
Das Adhikari Sikta, Cui Yuehua, Wang Jianrong
Abstract excerpt
Genome-wide Association Studies (GWAS) methods have identified individual single-nucleotide polymorphisms (SNPs) significantly associated with specific phenotypes. Nonetheless, many complex diseases are polygenic and are controlled by multiple genetic variants that are usually non-linearly dependent. These genetic variants are marginally less effective and remain undetected in GWAS analysis. Kernel-based tests...
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