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Article

Using canonical correlation analysis to discover genetic regulatory variants.

PloS one - 13 May 2010

Naylor Melissa G, Lin Xihong, Weiss Scott T, Raby Benjamin A, Lange Christoph

Abstract excerpt

BACKGROUND: Discovering genetic associations between genetic markers and gene expression levels can provide insight into gene regulation and, potentially, mechanisms of disease. Such analyses typically involve a linkage or association analysis in which expression data are used as phenotypes. This approach leads to a large number of multiple comparisons and may therefore lack power. We assess the potential of...

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Identifiers

PMID: 20485529
DOI: 10.1371/journal.pone.0010395
PMCID: PMC2869348

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Source receipt: pubmed, retrieved 7 Sept 2026.

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