Article
Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies.
Computational and mathematical methods in medicine - 1 Jan 2017
Friedrichs Stefanie, Manitz Juliane, Burger Patricia, Amos Christopher I, Risch Angela, Chang-Claude Jenny, Wichmann Heinz-Erich, Kneib Thomas, Bickeböller Heike, Hofner Benjamin
Abstract excerpt
The analysis of genome-wide association studies (GWAS) benefits from the investigation of biologically meaningful gene sets, such as gene-interaction networks (pathways). We propose an extension to a successful kernel-based pathway analysis approach by integrating kernel functions into a powerful algorithmic framework for variable selection, to enable investigation of multiple pathways simultaneously. We employ...
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