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Article

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase.

The Journal of cell biology - 15 Apr 2013

Lechtreck Karl F, Brown Jason M, Sampaio Julio L, Craft Julie M, Shevchenko Andrej, Evans James E, Witman George B

Abstract excerpt

The BBSome is a complex of seven proteins, including BBS4, that is cycled through cilia by intraflagellar transport (IFT). Previous work has shown that the membrane-associated signaling protein phospholipase D (PLD) accumulates abnormally in cilia of Chlamydomonas reinhardtii bbs mutants. Here we show that PLD is a component of wild-type cilia but is enriched ∼150-fold in bbs4 cilia; this accumulation occurs...

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Identifiers

PMID: 23589493
DOI: 10.1083/jcb.201207139
PMCID: PMC3628507

Genes

BBS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase.PMID 23589493Read ↗

The <i>Chlamydomonas reinhardtii</i> BBSome is an IFT cargo required for export of specific signaling proteins from flagellaSemantic proximity Read ↗

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Unraveling the Intricate Cargo-BBSome Coupling Mechanism at the Ciliary TipSemantic proximity Read ↗

ARL3 mediates BBSome ciliary turnover by promoting its outward movement across the transition zoneSemantic proximity Read ↗

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.Semantic proximity Read ↗

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.Semantic proximity Read ↗

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells.Semantic proximity Read ↗

The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.Semantic proximity Read ↗

The BBSome controls IFT assembly and turnaround in cilia.Semantic proximity Read ↗

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