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Article

The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.

The Journal of cell biology - 1 Oct 2012

Engel Benjamin D, Ishikawa Hiroaki, Wemmer Kimberly A, Geimer Stefan, Wakabayashi Ken-ichi, Hirono Masafumi, Craige Branch, Pazour Gregory J, Witman George B, Kamiya Ritsu, Marshall Wallace F

Abstract excerpt

The maintenance of flagellar length is believed to require both anterograde and retrograde intraflagellar transport (IFT). However, it is difficult to uncouple the functions of retrograde transport from anterograde, as null mutants in dynein heavy chain 1b (DHC1b) have stumpy flagella, demonstrating solely that retrograde IFT is required for flagellar assembly. We isolated a Chlamydomonas reinhardtii mutant...

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Identifiers

PMID: 23027906
DOI: 10.1083/jcb.201206068
PMCID: PMC3461521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.PMID 23027906Read ↗

A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport.Semantic proximity Read ↗

In vivo analysis of outer arm dynein transport reveals cargo-specific intraflagellar transport properties.Semantic proximity Read ↗

The FLA3 KAP subunit is required for localization of kinesin-2 to the site of flagellar assembly and processive anterograde intraflagellar transport.Semantic proximity Read ↗

Imaging intraflagellar transport in mammalian primary cilia.Semantic proximity Read ↗

Genetic and phenotypic analysis of flagellar assembly mutants in Chlamydomonas reinhardtii.Semantic proximity Read ↗

Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects.Semantic proximity Read ↗

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase.Semantic proximity Read ↗

The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.Semantic proximity Read ↗

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Probing the role of IFT particle complex A and B in flagellar entry and exit of IFT-dynein in Chlamydomonas.Semantic proximity Read ↗

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