Article
The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
Molecular biology of the cell - 1 Dec 2006
Blacque Oliver E, Li Chunmei, Inglis Peter N, Esmail Muneer A, Ou Guangshuo, Mah Allan K, Baillie David L, Scholey Jonathan M, Leroux Michel R
Abstract excerpt
The assembly and maintenance of cilia require intraflagellar transport (IFT), a microtubule-dependent bidirectional motility of multisubunit protein complexes along ciliary axonemes. Defects in IFT and the functions of motile or sensory cilia are associated with numerous human ailments, including polycystic kidney disease and Bardet-Biedl syndrome. Here, we identify a novel Caenorhabditis elegans IFT gene,...
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