Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The BBSome controls IFT assembly and turnaround in cilia.

Nature cell biology - 1 Sept 2012

Wei Qing, Zhang Yuxia, Li Yujie, Zhang Qing, Ling Kun, Hu Jinghua

Abstract excerpt

The bidirectional movement of intraflagellar transport (IFT) particles, which are composed of motors, IFT-A and IFT-B subcomplexes, and cargoes, is required for the biogenesis and signalling of cilia(1,2). A successful IFT cycle depends on the proper assembly of the massive IFT particle at the ciliary base and its turnaround from anterograde to retrograde transport at the ciliary tip. However, how IFT assembly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bardet-Biedl Syndrome
Share to Biological Transport
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Cell Line, Transformed

Share to Flagella

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 22922713
DOI: 10.1038/ncb2560
PMCID: PMC3434251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The BBSome controls IFT assembly and turnaround in cilia.PMID 22922713Read ↗

Functional coordination of intraflagellar transport motors.Semantic proximity Read ↗

Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.Semantic proximity Read ↗

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motorsSemantic proximity Read ↗

Architecture of the IFT ciliary trafficking machinery and interplay between its componentsSemantic proximity Read ↗

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.Semantic proximity Read ↗

The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.Semantic proximity Read ↗

Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.Semantic proximity Read ↗

IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.Semantic proximity Read ↗

Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.Semantic proximity Read ↗

An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.Semantic proximity Read ↗

Two-step process regulating the ciliary entrance of non-ciliary proteins: BBSome functions in the first step, upstream of the ciliary gateSemantic proximity Read ↗

Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.