Article
The Bardet-Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018
Liu Peiwei, Lechtreck Karl F
Abstract excerpt
Bardet-Biedl syndrome (BBS) is a ciliopathy resulting from defects in the BBSome, a conserved protein complex. BBSome mutations affect ciliary membrane composition, impairing cilia-based signaling. The mechanism by which the BBSome regulates ciliary membrane content remains unknown. Chlamydomonas...
Topics
- Bardet-Biedl Syndrome
- Biological Transport
- Cell Membrane
- Chlamydomonas reinhardtii
- Cilia
- Flagella
- Fluorescence Recovery After Photobleaching
- Humans
- Mutation
- Phospholipase D
- Photochemical Processes
- Phototaxis
- Protein Domains
- Protein Transport
- Proteins
- Transgenes