Article
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Cell death and differentiation - 1 Dec 2016
Gebel Jakob, Luh Laura M, Coutandin Daniel, Osterburg Christian, Löhr Frank, Schäfer Birgit, Frombach Ann-Sophie, Sumyk Manuela, Buchner Lena, Krojer Tobias, Salah Eidarus, Mathea Sebastian, Güntert Peter, Knapp Stefan, Dötsch Volker
Abstract excerpt
Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumor-suppressor function of TAp73β. This can in principle be due to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.