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Article

Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escape.

Cancer immunology, immunotherapy : CII - 1 Jun 2008

Smahel Michal, Tejklova Pavla, Smahelova Jana, Polakova Ingrid, Mackova Jana

Abstract excerpt

Infection with high-risk types of human papillomavirus (HPV) can cause the development of malignant tumors. To study mechanisms responsible for immune escape of tumor cells infected with HPV16, we previously used mouse oncogenic TC-1 cells producing HPV16 E6 and E7 oncoproteins to derive TC-1 clones resistant to immunization against E7. We have found immunoresistance of the clones to correlate with the point...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17962940
DOI: 10.1007/s00262-007-0418-9
PMCID: PMC11030076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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