Article
Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990
Connolly J M, Hansen T H, Ingold A L, Potter T A
Abstract excerpt
The CD8 molecule on class I-reactive cytotoxic T lymphocytes (CTLs) is believed to function as a coreceptor along with the alpha beta T-cell receptor. Whereas the alpha beta T-cell receptor recognizes polymorphic residues in the alpha 1/alpha 2 domains of the class I molecule, the CD8 molecule is believed to recognize monomorphic class I residues. Our previous experiments suggested that residue 227 in the alpha 3...
Topics
- Amino Acids
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD8 Antigens
- Cytotoxicity, Immunologic
- Histocompatibility Antigens Class I
- Mice
- Mice, Inbred BALB C
- Mutation
- Plasmids