Article
Estrogen receptor α gene analysis in girls with central precocious puberty.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2013
Lee Hae Sang, Park Hong Kyu, Kim Kyung Hee, Ko Jung Hee, Kim You Jin, Yi Kyung Hee, Hwang Jin Soon
Abstract excerpt
OBJECTIVE: Estrogen is the final key factor that triggers the onset of puberty. The raised sensitivity of estrogen receptor, which may be caused by an estrogen receptor α (ERα) gene mutation or polymorphism, has been implicated in the etiology of precocious puberty. The aim of this study is to identify ERα gene mutations or polymorphisms in girls with central precocious puberty (CPP). METHODS: A total of 204...
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