Article
Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study.
BMC medical genetics - 25 May 2018
Soares-Jr José Maria, de Holanda Felisbela Soares, Matsuzaki Cézar Noboru, Sorpreso Isabel Cristina Esposito, de Arruda Veiga Eduardo Carvalho, de Abreu Luiz Carlos, Carvalho Kátia Cândido, Baracat Edmund Chada
Abstract excerpt
BACKGROUND: Precocious puberty (PP) is defined as premature pubertal development. Its consequences surpass the physical evidence of sexual maturity with the premature epiphyseal closure of the long bones and the reduction of adult stature by varied degrees. Central PP is characteristically dependent on GnRH and most of its causes are not completely known. Altered estrogen action is also believed to be involved in...
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