Article

The human-restricted oncoprotein POU5F1B enhances cell invasiveness through plasma membrane remodeling

2023-11-02

Abstract excerpt

Evolution confers new species with distinctive biological features that can translate in either purely mechanistic speciation or novel phenotypes. Retrotransposition in the last Hominidae common ancestor of the pluripotency regulator POU5F1/OCT4 led to human POU5F1B, which promotes gastrointestinal cancer growth and metastasis through unknown mechanisms. Here, we show that POU5F1B fosters cell invasiveness by ind...

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Literature Corpus work: 840f729c-a002-5d34-9954-dfdcc17feb5f
DOI: 10.1101/2023.10.30.564723

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