Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factor Oct1 is a somatic and cancer stem cell determinant.

PLoS genetics - 1 Jan 2012

Maddox Jessica, Shakya Arvind, South Samuel, Shelton Dawne, Andersen Jared N, Chidester Stephanie, Kang Jinsuk, Gligorich Keith M, Jones David A, Spangrude Gerald J, Welm Bryan E, Tantin Dean

Abstract excerpt

Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription states, regulates normal and pathologic stem cell function. Oct1(HI) cells in the colon and small intestine co-express known stem cell markers. In primary malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase
Share to CD24 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyaluronan Receptors

Share to Intestine, Small

Share to Neoplastic Stem Cells

Share to Organic Cation Transporter 1

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 23144633
DOI: 10.1371/journal.pgen.1003048
PMCID: PMC3493455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factor Oct1 is a somatic and cancer stem cell determinant.PMID 23144633Read ↗

Oct1/Pou2f1 is selectively required for gut regeneration and regulates gut malignancySemantic proximity Read ↗

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancySemantic proximity Read ↗

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of QuiescenceSemantic proximity Read ↗

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.Semantic proximity Read ↗

Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation.Semantic proximity Read ↗

Prox1 Promotes Expansion of the Colorectal Cancer Stem Cell Population to Fuel Tumor Growth and Ischemia ResistanceSemantic proximity Read ↗

Oct4 expression in adult stem cells: evidence in support of the stem cell theory of carcinogenesisSemantic proximity Read ↗

Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cellsSemantic proximity Read ↗

Stem Cell Marker OCT3/4 in Tumor Biology and Germ Cell Tumor Diagnostics: History and FutureSemantic proximity Read ↗

[Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance].Semantic proximity Read ↗

Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovarySemantic proximity Read ↗

The human organic cation transporter OCT1 and its role as a target for drug responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.