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Applications of post-translational modifications of FoxO family proteins in biological functions

13 Jun 2011

Abstract excerpt

The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding,...

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PMID: 21669942
DOI: 10.1093/jmcb/mjr013

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