Article
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.
Genes & development - 15 Jan 2009
Kang Jinsuk, Gemberling Matthew, Nakamura Mitsuhiro, Whitby Frank G, Handa Hiroshi, Fairbrother William G, Tantin Dean
Abstract excerpt
Oct1 and Oct4 are homologous transcription factors with similar DNA-binding specificities. Here we show that Oct1 is dynamically phosphorylated in vivo following exposure of cells to oxidative and genotoxic stress. We further show that stress regulates the selectivity of both proteins for specific DNA sequences. Mutation of conserved phosphorylation target DNA-binding domain residues in Oct1, and Oct4 confirms...
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