Article
High-resolution structure of a mutagenic lesion in DNA.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Leonard G A, Thomson J, Watson W P, Brown T
Abstract excerpt
The self-complementary dodecanucleotide d[CGC(m6G)AATTTGCG]2 (where m6G is O6-methylguanine), which contains two m6G.T base pairs, has been analyzed by x-ray diffraction methods and the structure has been refined to a residual error of R = 0.185 at 2.0-A resolution. The m6G.T mispair closely rese...
Topics
- Base Composition
- Base Sequence
- DNA
- Guanine
- Hydrogen Bonding
- Hydrogen-Ion Concentration
- Models, Genetic
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleic Acid Denaturation
- Oligodeoxyribonucleotides
- X-Ray Diffraction