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Article

Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats.

PloS one - 1 Jan 2013

Liška František, Gosele Claudia, Popova Elena, Chylíková Blanka, Křenová Drahomíra, Křen Vladimír, Bader Michael, Tres Laura L, Hubner Norbert, Kierszenbaum Abraham L

Abstract excerpt

Rat hypodactyly (hd) mutation is characterized by abnormal spermatogenesis and sperm decapitation, limb malformation (missing digits II and III) and growth retardation. We have previously reported centrobin (centrosome BRCA2-interacting protein) truncation at the C-terminus in the hd mutant. Here, we report data from a transgenic rescue experiment carried out to determine a role of centrobin in pathogenesis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23577170
DOI: 10.1371/journal.pone.0060859
PMCID: PMC3620055

Genes

BRCA2
ODF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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