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Article

The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.

Developmental biology - 15 Dec 2011

Berkovits Binyamin D, Wolgemuth Debra J

Abstract excerpt

Mice homozygous for a mutation (Brdt(∆BD1/∆BD1)) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during spermiogenesis. We have now observed that a prominent feature of the aberrant spermatid nuclei is a fragmented chromocenter, a structure comprised of peri-centromeric...

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Identifiers

PMID: 22020252
DOI: 10.1016/j.ydbio.2011.10.005
PMCID: PMC3217133

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