Article
The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.
Developmental biology - 15 Dec 2011
Berkovits Binyamin D, Wolgemuth Debra J
Abstract excerpt
Mice homozygous for a mutation (Brdt(∆BD1/∆BD1)) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during spermiogenesis. We have now observed that a prominent feature of the aberrant spermatid nuclei is a fragmented chromocenter, a structure comprised of peri-centromeric...
Topics
- Animals
- Chromatin
- Chromatin Assembly and Disassembly
- Crosses, Genetic
- Fluorescent Antibody Technique
- Histones
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Nuclear Proteins
- Sirtuin 1
- Spermatids
- Spermatogenesis
- Testis