A dominant negative allele of the Drosophila leucine zipper protein Bunched blocks bunched function during tissue patterning.

doi:10.1016/j.mod.2007.05.003

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Article

A dominant negative allele of the Drosophila leucine zipper protein Bunched blocks bunched function during tissue patterning.

Mechanisms of development - 1 Aug 2007

Ash David M, Hackney Jennifer F, Jean-Francois Michele, Burton Neal C, Dobens Leonard L

Abstract excerpt

The bunched (bun) gene encodes the Drosophila member of the TSC-22/GILZ family of leucine zipper transcriptional regulators. The bun locus encodes multiple BUN protein isoforms and has diverse roles during patterning of the eye, wing margin, dorsal notum and eggshell. Here we report the construction and activity of a dominant negative allele (BunDN) of the BUN-B isoform. In the ovary, BunDN expression in the...

Topics

Animals
Body Patterning
Cadherins
Cell Shape
Drosophila
Drosophila Proteins
Epithelium
Female
Mutation
Ovarian Follicle

Source

Open in PubMed

Identifiers

PMID: 17600691
DOI: 10.1016/j.mod.2007.05.003

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