Article
Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus.
Biology of reproduction - 1 Dec 2009
Liska Frantisek, Gosele Claudia, Rivkin Eugene, Tres Laura, Cardoso M Cristina, Domaing Petra, Krejcí Eliska, Snajdr Pavel, Lee-Kirsch Min Ae, de Rooij Dirk G, Rooij Dirk G de, Kren Vladimír, Krenová Drahomíra, Kierszenbaum Abraham L, Hubner Norbert
Abstract excerpt
The hypodactylous (hd) locus impairs limb development and spermatogenesis, leading to male infertility in rats. We show that the hd mutation is caused by an insertion of an endogenous retrovirus into intron 10 of the Cntrob gene. The retroviral insertion in hd mutant rats disrupts the normal splicing of Cntrob transcripts and results in the expression of a truncated protein. During the final phase of...
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