Article
The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail.
Developmental biology - 1 Sept 2005
Samant Sadhana A, Ogunkua Olugbemiga O, Hui Ling, Lu Jing, Han Yibing, Orth Joanne M, Pilder Stephen H
Abstract excerpt
Heterozygosity for a t haplotype (t) in male mice results in distorted transmission (TRD) of the t-bearing chromosome 17 homolog to their offspring. However, homozygosity for t causes male sterility, thus limiting the spread of t through the population at large. The Ca(2+)-dependent sperm tail curvature phenotypes, "fishhook", where abnormally high levels of sperm exhibit sharp bends in the midpiece, and...
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