Tissue-specific microtubule functions in Drosophila spermatogenesis require the beta 2-tubulin isotype-specific carboxy terminus.

Abstract excerpt

beta-Tubulins are encoded by members of multigene families and are generally highly conserved at the sequence level. The carboxyl terminal 15 amino acids are markedly more diverged than the rest of the sequence and constitute an "isotype defining region," which is conserved in corresponding beta-tubulin isoforms in different vertebrate species. It is thought that the carboxy terminus of beta-tubulin may not be...

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