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Article

Localization of BDNF mRNA with the Huntington's disease protein in rat brain

27 May 2010

Abstract excerpt

BACKGROUND: Studies have implicated reduced levels of brain-derived neurotrophic factor (BDNF) in the pathogenesis of Huntington's disease. Mutant huntingtin (Htt) protein was previously reported to decrease BDNF gene transcription and axonal transport of BDNF. We recently showed that wild-type Htt is associated with the Argonaute 2 microRNA-processing enzyme involved in gene silencing. In dendrites, Htt...

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PMID: 20507609
DOI: 10.1186/1750-1326-5-22

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Localization of BDNF mRNA with the Huntington's disease protein in rat brainPMID 20507609Read ↗

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