Article
Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
Cell cycle (Georgetown, Tex.) - 1 May 2013
Avena Paola, Anselmo Wanda, Whitaker-Menezes Diana, Wang Chenguang, Pestell Richard G, Lamb Rebecca S, Hulit James, Casaburi Ivan, Andò Sebastiano, Martinez-Outschoorn Ubaldo E, Lisanti Michael P, Sotgia Federica
Abstract excerpt
The role of PPARγ in cancer therapy is controversial, with studies showing either pro-tumorigenic or antineoplastic effects. This debate is very clinically relevant, because PPARγ agonists are used as antidiabetic drugs. Here, we evaluated if the effects of PPARγ on tumorigenesis are determined by the cell type in which PPARγ is activated. Second, we examined if the metabolic changes induced by PPARγ, such as...
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