Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anticancer activities of PPARγ in breast cancer are context-dependent.

The American journal of pathology - 1 Jun 2013

Dong Jin-Tang

Abstract excerpt

This Commentary highlights the article by Nakles et al, who described that PPARγ activation suppresses non-invasive tumor development and induces ER-positivity without affecting invasive tumor development.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticarcinogenic Agents
Share to Genes, BRCA1
Share to Mammary Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to PPAR gamma

Share to Thiazolidinediones

Source

Identifiers

PMID: 23619477
DOI: 10.1016/j.ajpath.2013.03.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anticancer activities of PPARγ in breast cancer are context-dependent.PMID 23619477Read ↗

Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progressionSemantic proximity Read ↗

Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independenceSemantic proximity Read ↗

Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progressionSemantic proximity Read ↗

The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.Semantic proximity Read ↗

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.Semantic proximity Read ↗

The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency.Semantic proximity Read ↗

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.Semantic proximity Read ↗

PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic DrugsSemantic proximity Read ↗

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancerSemantic proximity Read ↗

Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in CancerSemantic proximity Read ↗

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitorSemantic proximity Read ↗

PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.