Article

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis

2024-06-26

Abstract excerpt

<title>Abstract</title> <p>Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin (<italic>FLCN</italic>) knockdown was required to increase their tumorigenic potential, forming larger spheroids in non-adhere...

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Literature Corpus work: bad2a1cf-2392-52c8-945f-938d57d3ec73
DOI: 10.21203/rs.3.rs-4510670/v1

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