Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory.

Abstract excerpt

Inbred mouse strains are widely used for genetic studies because of the isogenicity within a strain or F1 hybrid and the genetic heterogeneity between inbred strains. In the process of modifying Disc1 in the mouse genome, a 25-bp deletion was discovered in exon 6 of the gene in the 129S6/SvEvTac inbred strain, and subsequently in 16 other inbred strains in the category known as ‘Castle’s mice’. The deletion...

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